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South Minahasa Regency is a regency in North Sulawesi, Indonesia. Its capital is the town of Amurang. It was originally part of the Minahasa Regency until it was established as a separate regency on 25 February 2003. In turn, nearly four years later, a new Southeast Minahasa Regency was established as a separate regency from part of the South Minahasa Regency on 2 January 2007. The residual Regency now covers an area of 1,456.74 km2, and had a population of 195,553 at the 2010 Census; this had risen to 236,463 at the 2020 Census; the official estimate as at mid 2025 was 243,519.

Kabupaten Minahasa Selatan dibentuk berdasarkan Undang-undang Nomor 10 Tahun 2003. Wilayah Kabupaten Minahasa Selatan berasal dari kecamatan-kecamatan dari Kabupaten Minahasa yaitu Belang, Modoinding, Motoling, Ranoyapo, Ratahan, Sinonsayang, Tenga, Tareran, Tombasian, Tombatu, Tompaso Baru, Touluaan, dan Tumpaan. Pada tahun 2007, Kabupaten Minahasa Tenggara dibentuk atas hasil pemekaran Kabupaten Minahasa Selatan berdasarkan Undang-undang Nomor 9 Tahun 2007.

Amurang, the seat of the regency has a tropical rainforest climate (Af) with moderate rainfall from July to September and heavy rainfall in the remaining months.