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Pasangkayu Regency is one of the six regencies which comprise West Sulawesi Province, Indonesia, on the island of Sulawesi. It covers an area of 3,043.75 km2 and had a population of 134,303 at the 2010 Census and 188,861 at the 2020 Census. The official estimate as at mid 2025 was 184,371 (comprising 94,720 males and 89,651 females). The majority of the indigenous population speak the Kaili language, also indigenous in the southern part of Donggala Regency and in Sigi Regency to the east. The town of Pasangkayu is the capital and chief town of the regency.

The regency was initially named North Mamuju Regency from its creation on 25 February 2003 (from the former northern districts of Mamuju Regency), until it was renamed as Pasangkayu Regency in March 2018.

Pasangkayu has a tropical rainforest climate (Af) with heavy rainfall year-round.